Business Dev.

DM Technologies: Drug pre-screening systems (DM 2000, DM 2010)- Narcotics pre-screening of human subjects through pupil reaction analysis

Iris Identification System with Facial Recognition (Iris 2000)- The most accurate method of identification and verification of a person's identity through iris & facial image analysis

Binocular Irido-Diagnostic Camera System (I-CON 2000) - Binocular iridology camera system to capture color iris images

With Iritech’s DM Technologies you can have a subject look into a binocular device for a brief moment and diagnose his/her body for narcotics. Is your environment one where you perform hundreds or thousands of urine or blood analysis tests? The DM Technologies are your answer to limiting the number of tests performed. Iritech’s DM Technologies would allow you to pre-screen candidates to determine if they have narcotics in their system without incurring lab expenses.

The pre-screening process would not be drug specific, but would establish probable casue for further testing. In short, the DM Technologies will be the breathalyzers for narcotics and the key benefit that this would provide corrections, law enforcement, military, pre-employment, and transportation markets will be tremendous cost savings as the cost per test is no longer a factor since the DM Technologies are software driven.

The DM Technologies expose the pupil to brief flash of light and then approximately 40 different parameters are analyzed and evaluations on the human subject are virtually instantaneous. This process is performed 3 times to allow for the most accurate drug detection. Although the algorithms that drive the software are very intricate and required over 20,000 human subjects to develop, the technology itself is most easy to operate as it is merely a point and click technology. With the ability to integrate with any database system the software will allow for the most rapid and cost effective means to test populations for narcotics.

Independent Clinical Tests have been performed at Duke University, Moscow State University and at Korean Government Drug Clinics to determine accuracies that have been ranged between 85.7% and 98%. With more than 1700 subjects total in these studies, the empirical proof of the DM Technologies is clear.

System description is the same as DM 2000, but it boasts portability as it has a built in handle. No System Requirements as this model has a PC built into it. It also has the ability to be linked to a network to allow for communication with existing databases.

Conventional drug detection methods, such as urine, blood, and hair test, have many limitations. The Company’s drug screen system (DM-2010) provides fast, highly accurate, low-cost, and non-invasive method, which can detect the use of illicit drugs. The DM-2010’s competitive advantage is its proprietary software that works with the use of IriTech’ specific camera to capture its subjects’ pupil image. The image is taken by a binocular looking camera system, which takes three sets of images that are instantly sent to the PC. The synchronous and dynamic binocular image depicts the reaction of the pupil to a flashing light. It can be used as a preliminary test much like the Breathalyzer test and is just as easy to conduct. The subject sits down in front of the DM-2010 and looks into the device. The operator then instructs the subject on where to position his head and with the click of the mouse the image is captured. The image is processed and the pupil’s reactions are graphed on a pupillogram. State of vegetative nervous system at the moment of the examination is estimated by further pupillogram processing. The obtained data is used for intoxication detection and also can be used for estimation of patient’s starting capability, reaction type, fatigue degree, disturbance of vegetative balance of different genesis etc. Possibility of such estimation is included to software as “Reflexometer conclusion” mode. With its key technology in the software, the test conductor will learn the results within seconds. These systems will find applications in vertical market segments including law enforcement agencies, correctional institutions, collection sites, and reference laboratories.

As a by-product of its work in the development of a sophisticated iris mapping technology for personal identification applications, IriTech has developed the only non-invasive, commercial drug detection system of its kind. It is in the public interest to identify offenders and curtail their activities that might adversely impact others (e.g. driving under the influence of drugs, presence on elementary school campuses, etc.). Currently available drug monitoring methods are invasive, have a slow response time, and are useful for detecting only recent abuse. They are also prone to manipulation. Information is readily available over the Internet describing in detail how to dope urine samples for pre-employment drug screening, using common substances such as aspirin to mask certain illicit drugs.

The Company believes that unobtrusive testing will be more readily accepted by the public, and will be faster and easier to administer. The potential market for the drug detection system was estimated as $2 billion in 2000.

TODAY’S DRUG DETECTION MARKET

URINE AND BLOOD TESTING

Ø Invasive

Ø Slow response time

Ø Detect only recent abuse

Ø Prone to manipulation

Ø New re-agents must constantly be developed to detect new drugs

Ø Costly

Ø $1.6 Billion Market

DM Technology

1. Base line not required

2. Both eyes evaluated

3. 40 different parameters evaluated

4. Clinical tests using more than 15,000 human tests

5. Ability to upgrade iris identification into same hardware

6. Inexpensive

7. Patented

Milestones:

1. Complete pilot programs and market results.

2. Complete sale to reference account within corrections.

3. Complete licensing agreement with major urine analysis company.

Key Relationships:

1. Pilot programs.

2. Systems integration companies for installation and training outsourcing.

3. Government regulatory organizations: SAMSHA, NIDA DRE, DEA etc.

4. Public Relations: press, media, policy decision-makers, industry analysts.

The list of drugs, which can change the pupil reaction

Cause miosis

1. Acetylcholine and cholinomimetics

1. Carbacholinum	4. Coordinax
2. Aceclidinum	5. Aminopiridin
3. Cisapride	6. Pilocarpinum

2. Inhibitors of cholinesterase

7. Physostigminum	12. Aminostigminum
8. Galanthaminum	13. Amiridinum
9. Proserinum	14. Tacrine
10. Oxazylum	15. Stephaglabrinum
11. Chinotilinum	16. Arminum

3. Narcotic's (opiats like) analgetics

17. Morphinum	26. Lepetan
18. Morphilongum	27. Butorphanol
19. Omnoponum	28. Moradol
20. Codeinum	29. Promedolum
21. Pentazocine	30. Phentanylum
22. Nalbuphine	31. Sentonyl
23. Nubain	32. Tramadol
24. Buprenorphine	33. Mabron
25. Anfin	34. Metadon

Cause midriasis

1. Adrenostimulators

35. Adrenalinum	Phethanolum
36. Noradrenalinum	Ephedrinum
37. Mesatonum	Naphthyzinum

2. Cholinolitics

41. Atropinum	48. Fubromeganum
42. Scopolaminum	49. Mydriacyl
43. Homtropinum	50. Atrovent
44. Platyphyllinum	51. Berodual
45. Vagospasmyl	52. Troventolum
46. Aprophenum	53. Arpenalum
47. Methacinum

3. Ganglioblocators

54. Benzohexonium	58. Hygronium
55. Pentaminum	59. Quateronum
56. Dimecolinum	60. Pachycarpinum
57. Imechinum	61. Tenormal

4. Psychomotor stimulators

62. Phenaminum	64. Alentol
63. Aktedrin	65. Isoamin

Reduse the pupill reaction

1. Hypnotics

66. Nitrzepam	74. Estazolam
67. Radedorm	75. Brotizolam
68. Dormicum	76. Triazolam
69. Phenazepamum	77. Midazolam
70. Еunoctin	78. Imovan
71. Insomin	79. Ivadal
72. Sedex	80. Doxylamine
73. Valsera	81. Heminevrin

2. Anticonvulsive

82. Adonal	87. Clonazepame
83. Mysoline	88. Acediprolum
84. Alepsin	89. Lamotrigine
85. Trimethinum	90. Lioresal
86. Finlepsin

3. Neuroleptics

91. Aminazinum	94. Tisercin
92. Neuroleptil	95. Neuropax
93. Sediston

4. Antihistaminics

96. Dimedrolum	98. Tavegil
97. Diprazinum	99. Loridex

Appendix : Related Materials

1. Drug Testing Under Fire In Air Academy Scandal.

Drug Testing Under Fire In Air Academy Scandal

Posted by FoM on February 07, 2001 at 07:55:43 PT
By Judith Graham, Tribune Staff Writer
Source: Chicago Tribune

A major drug scandal at the U.S. Air Force Academy is highlighting concern that cadets are using illegal substances such as Ecstasy that are difficult to detect with standard drug tests. The scandal has prompted talk of a congressional investigation.

The investigation entered a new phase in the past week, as one cadet, senior Stephen Pouncey, 22, was court-martialed Jan. 31 and sentenced to 42 months in military prison in Leavenworth, Kan., for using and distributing drugs such as Ecstasy and LSD.

Sophomore Cadet Barton Duvall has been charged with taking LSD and could be court-martialed in a hearing Wednesday. He faces up to 5 years in prison.

A third cadet resigned under pressure last month, and 11 others are under investigation in the drug scandal, the largest ever at the academy. Nine other cadets have been put on probation for knowing about students' misbehavior but not telling authorities.

The scandal is "a big black eye for the academy," which trains future Air Force officers and fighter pilots on the outskirts of Colorado Springs, said Sarah Sheldon, spokeswoman for Rep. Joel Hefley (R-Colo.).

"We are deeply disturbed," said academy spokesman Neil Talbott. "Our cadets know their actions have consequences. And because of the responsibilities we trust them with, we hold them to a higher standard."

Faced with criticism from Hefley concerning their drug-testing policies, academy officials have promised to step up random tests and commander-ordered tests, especially on weekends and holidays when senior cadets tend to leave campus, Talbott said. Officials are also working to develop more sensitive tests.

Last year, the school conducted urinalysis on about 2,600 of its 4,100 cadets. The current investigation began in October after a test showed positive for drugs.

The scandal underscores the dangers that drugs such as Ecstasy pose to military academies' efforts to combat drug use. Five of the 14 cadets being investigated are believed to have used Ecstasy, according to a mid-January briefing by academy Vice Supt. Brian Binn. Other drugs reportedly involved include marijuana, LSD and Blue Nitro, a sleep aid and muscle builder also known as

Verve and Midnight Blue.

Since Ecstasy is flushed out of a person's system in less than a day, much more rapidly than other illegal drugs, it is harder to discover its use with episodic testing.

"Clearly, there's a changing dynamic out there with new drugs like Ecstasy that are not detectable by traditional drug-testing policies," said Sean Conway, press secretary for Sen. Wayne Allard (R-Colo.), who is on the Armed Services Committee.

The potential for undetected abuse "is not just an Air Force Academy problem--it's a problem for all the military academies and for the military servicewide," Conway said.

Underscoring Allard's concern, a separate, unrelated investigation by the Air Force in Colorado Springs is looking into the alleged use of Ecstasy, LSD and marijuana by 15 enlisted personnel at Peterson Air Force Base and Cheyenne Mountain Air Force Station.

Allard's spokesman said the senator is worried about the lack of a uniform drug-testing policy at the nation's three military academies--the U.S. Military Academy at West Point, N.Y., the U.S. Naval Academy at Annapolis, Md., and the Air Force Academy--and may ask Congress to look into the testing programs.

At the Air Force Academy, 35 cadets initially were investigated. Twelve were exonerated; nine were found to have concealed information; and 14 became the main targets of the probe, which has been conducted by academy security staff and the Air Force Office of Special Investigations.

At his Jan. 31 court-martial hearing, Pouncey said another cadet introduced him to Ecstasy in May. In October, he said he tried LSD and cocaine at clubs in Denver. After a commander requested a urinalysis on Oct. 16 and Pouncey's results turned up positive, the cadet began cooperating with investigators.

Drug problems crop up at all three service academies on an intermittent basis. But in addition to the unfolding scandal at the Air Force Academy, West Point in December began investigating four cadets who were found to have taken a drug known as ketamine or "Special K," used primarily as an anesthetic for large animals. Like Ecstasy, it is difficult to detect, said West Point spokesman James Whaley.

Source: Chicago Tribune (IL)
Author: Judith Graham, Tribune Staff Writer
Published: February 07, 2001
Address: 435 N. Michigan Ave., Chicago, IL 60611-4066

MIT Journal Article

Pupils to the Test

Urine and blood tests can usually only detect substances consumed in the past two to three days. A new technique, devised by Iritech in San Jose, CA, screens for longer-term drug use—up to two weeks—by looking at eye response. A person looks into a binocular-like camera and is exposed to a flash of light. Software calculates how quickly the pupils shrink and recover, compares this response against pupil records stored in a database, and gauges within seconds whether the subject has taken drugs or alcohol during the past several weeks. i

Iritech CEO Daniel Daehoon Kim says the test would be best suited as a screening tool for prsons or for employers evaluating job applicants. One possible drawback: some legitimate medications, such as antiseizure drugs, affect pupil response and could cause false positives. The technology is 95 percent accurate, based on clinical studies involving more than 12,000 subjects. The company hopes to give the system its first real-world test this year at a prison in Santa Clara, CA.

The Company believes that unobtrusive testing will be more readily accepted by the public, and will be faster and easier to administer. The potential market for the drug detection system was estimated as $2 billion in 2000.

9. Proserinum